3. Would the point item give me more points than the effect item would give?
If yes, then GET THE POINT ITEM
If no, then GET THE EFFECT ITEMI would change that to
3. Are you able to get the point item
and the effect item?
If yes, RUN!
If no, go to #4
4. Would the point item give me more points than the effect item would give?
If yes, then GET THE POINT ITEM
If no, then GET THE EFFECT ITEM
And for #4, you also have to think of the fruits. For example if you can get the big yellow crystal, it is worth more than

or

and the red one can be worth more than

too.
And
never overrate

! It is worth
nothing without the 50k bonus. Okay, not nothing, but most of the point items (combined with the fruits' crystals) are worth more.
I have taken this several times in levels like 8 or 33 where it is impossible to reach all the stones (33 is possible with the key, but you have to be very fast and you will have to go to PD33). So if you can't get the 50k bonus, you will have to think about taking it.
The other pearls are worth enough, of course.